Faculty
Oncology Division
Alphabetical list (active faculty):   
John S. Welch

John S. Welch, MD, PhD

Associate Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Research Interests

  • Acute myeloid leukemia
  • Myelodysplastic syndrome
  • Genomics

Contact

  • 314-362-2626 (office)
  • 314-362-9333 (fax)
  • Division of Oncology
    Mail Stop 8007-0057-06
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Southwest Tower, Room 621 (office)
  • Southwest Tower, Room 613L (lab)

Peer-reviewed Manuscripts

  • Cytokine Exposure Mediates Transcriptional Activation of the Orphan Nuclear Receptor Nur77 in Hematopoietic Cells
    di Martino O, Niu H, Hadwiger G, Ferris MA, Welch JS
    J Biol Chem 2021 Sep 24:101240; [Epub ahead of print]
  • Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
    Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, DiPersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
    JCO Precis Oncol 2021 Jan 14;5
  • Bexarotene Derivatives Modify Responses in Acute Myeloid Leukemia
    Hadwiger G, di Martino O, Ferris MA, Vu A, Frederick TE, Bowman GR, Ruminski P, Wagner C, Welch JS
    bioRxiv 2021 May 17;444475
  • RXRA DT448/9PP Generates a Dominant Active Variant Capable of Inducing Maturation in Acute Myeloid Leukemia Cells
    Di Martino O, Ferris MA, Hadwiger G, Sarkar S, Vu A, Menendez-Gutierrez MP, Ricote M, Welch JS
    Haematologica 2021 Jun 17; [Epub ahead of print]
  • Outcomes of Relapsed or Refractory Acute Myeloid Leukemia After Frontline Hypomethylating Agent and Venetoclax Regimens
    Maiti A, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur G, Naqvi K, Ohanian M, Short NJ, Alvarado Y, Kadia TM, Takahashi K, Yilmaz M, Jain N, Kornblau S, Montalban Bravo G, Sasaki K, Andreeff M, Bose P, Ferrajoli A, Issa GC, Jabbour EJ, Masarova L, Thompson PA, Wang S, Konoplev S, Pierce SA, Ning J, Qiao W, Welch JS, Kantarjian HM, DiNardo CD, Konopleva MY
    Haematologica 2021 Mar 1;106(3):894-898
  • Endogenous and Combination Retinoids Are Active in Myelomonocytic Leukemias
    Di Martino O, Niu H, Hadwiger G, Kuusanmaki H, Ferris MA, Vu A, Beales J, Wagner C, Menendez-Gutierrez MP, Ricote M, Heckman C, Welch JS
    Haematologica 2020 Nov 26
  • 10-Day Decitabine With Venetoclax for Newly Diagnosed Intensive Chemotherapy Ineligible, and Relapsed or Refractory Acute Myeloid Leukaemia: A Single-Centre, Phase 2 Trial
    DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
    Lancet Haematol 2020 Oct;7(10):e724-e736
  • Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy
    Martino OD, Welch JS
    Cancers (Basel) 2019 Dec 1;11(12):1915
  • Serendipity: Decitabine Monotherapy Induced Complete Molecular Response in a 77-Year-Old Patient With Acute Promyelocytic Leukemia
    Abboud R, Han SY, Duncavage EJ, Cashen AF, Shirai CL, Welch JS, DiPersio JF, Abboud CN
    Haematologica 2019 Apr;104(4):e170-e173
  • TP53 Immunohistochemistry Correlates With TP53 Mutation Status and Clearance in Decitabine-Treated Patients With Myeloid Malignancies
    Ruzinova MB, Lee YS, Duncavage EJ, Welch JS
    Haematologica 2019 Aug;104(8):e345-e348
  • Smc3 Is Required for Mouse Embryonic and Adult Hematopoiesis
    Wang T, Glover B, Hadwiger G, Miller CA, di Martino O, Welch JS
    Exp Hematol 2019 Feb;70:70-84e6
  • Exome Analysis of Treatment-Related AML After APL Suggests Secondary Evolution
    Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS
    Br J Haematol 2019 Jun;185(5):984-987
  • Cellular Stressors Contribute to the Expansion of Hematopoietic Clones of Varying Leukemic Potential
    Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
    Nat Commun 2018 Jan 31;9(1):455
  • Subclones Dominate at MDS Progression Following Allogeneic Hematopoietic Cell Transplant
    Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
    JCI Insight 2018 Mar 8;3(5)
  • Immune Escape of Relapsed AML Cells After Allogeneic Transplantation
    Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, Baty JD, Payton JE, Graubert TA, Link DC, Walter MJ, Westervelt P, Ley TJ, DiPersio JF
    N Engl J Med 2018 Dec 13;379(24):2330-2341
  • Mutation Clearance After Transplantation for Myelodysplastic Syndrome
    Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
    N Engl J Med 2018 Sep 13;379(11):1028-1041
  • A Case of Acute Myeloid Leukemia With Promyelocytic Features Characterized by Expression of a Novel RARG-CPSF6 Fusion
    Miller CA, Tricarico C, Skidmore ZL, Uy GL, Lee YS, Hassan A, O'Laughlin MD, Schmidt H, Tian L, Duncavage EJ, Griffith M, Griffith OL, Welch JS, Wartman LD
    Blood Adv 2018 Jun 12;2(11):1295-1299
  • Lenalidomide Results in a Durable Complete Remission in Acute Myeloid Leukemia Accompanied by Persistence of Somatic Mutations and a T-Cell Infiltrate in the Bone Marrow
    Bansal D, Vij K, Chang GS, Miller CA, DiPersio JF, Vij R, Heath SE, Westervelt P, Welch JS*, Fehniger TA* (*contributed equally)
    Haematologica 2018 Jun;103(6):e270-e273
  • Patterns of Infectious Complications in Acute Myeloid Leukemia and Myelodysplastic Syndromes Patients Treated With 10-Day Decitabine Regimen
    Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
    Cancer Med 2017 Dec;6(12):2814-2821
  • Endogenous Retinoid X Receptor Ligands in Mouse Hematopoietic Cells
    Niu H, Fujiwara H, di Martino O, Hadwiger G, Frederick TE, Menendez-Gutierrez MP, Ricote M, Bowman GR, Welch JS
    Sci Signal 2017 Oct 31;10(503)
  • Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Welch JS*, Petti AA*, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ (*contributed equally)
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Pathways of Retinoid Synthesis in Mouse Macrophages and Bone Marrow Cells
    Niu H, Hadwiger G, Fujiwara H, Welch JS
    J Leukoc Biol 2016 Jun;99(6):797-810
  • Hand-Foot Syndrome Following Decitabine
    Ali AM, Jacoby M, Welch JS
    Ann Hematol 2016 Feb;95(3):535-6
  • Rapid Expansion of Preexisting Nonleukemic Hematopoietic Clones Frequently Follows Induction Therapy for De Novo AML
    Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
    Blood 2016 Feb 18;127(7):893-7
  • Absence of Natural Intracellular Retinoids in Mouse Bone Marrow Cells and Implications for PML-RARA Transformation
    Niu H, Chacko J, Hadwiger G, Welch JS
    Blood Cancer J 2015 Feb 27;5:e284
  • Genomic Analysis of Germ Line and Somatic Variants in Familial Myelodysplasia/Acute Myeloid Leukemia
    Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
    Blood 2015 Nov 26;126(22):2484-90
  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Patterns and Functional Implications of Rare Germline Variants Across 12 Cancer Types
    Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, DiPersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
    Nat Commun 2015 Dec 22;6:10086
  • Role of TP53 Mutations in the Origin and Evolution of Therapy-Related Acute Myeloid Leukaemia
    Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
    Nature 2015 Feb 26;518(7540):552-555
  • SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
    Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
    PLoS Comput Biol 2014 Aug 7;10(8):e1003665
  • A Phase I Dose Escalation Study of Oral Bexarotene in Combination With Intravenous Decitabine in Patients With AML
    Welch JS, Niu H, Uy GL, Westervelt P, Abboud CN, Vij R, Stockerl-Goldstein KE, Jacoby M, Pusic I, Schroeder MA, DiPersio JF, Cashen AF
    Am J Hematol 2014 Aug;89(8):E103-8
  • Age-Related Mutations Associated With Clonal Hematopoietic Expansion and Malignancies
    Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
    Nat Med 2014 Dec;20(12):1472-1478
  • Mutational Landscape and Significance Across 12 Major Cancer Types
    Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, Ley TJ, Wilson RK, Raphael BJ, Ding L
    Nature 2013 Oct 17;502(7471):333-9
  • Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
    Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
    N Engl J Med 2013 May 30;368(22):2059-74
  • Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
    Wartman LD*, Welch JS*, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ (*contributed equally)
    PLoS One 2012;7(10):e46529
  • Solid, Low-Attenuation Splenic Lesions on Computed Tomography in Patients With Indolent Lymphoma Often Signal Transformation: A Series of Ten Patients
    Welch JS, Foyil KV, Powers ML, Middleton WD, Bartlett NL
    Clin Lymphoma Myeloma Leuk 2012 Dec;12(6):452-4
  • The Origin and Evolution of Mutations in Acute Myeloid Leukemia
    Welch JS*, Ley TJ*, Link DC*, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK (*contributed equally)
    Cell 2012 Jul 20;150(2):264-78
  • Clonal Evolution in Relapsed Acute Myeloid Leukaemia Revealed by Whole-Genome Sequencing
    Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF
    Nature 2012 Jan 11;481(7382):506-10
  • Combination Decitabine, Arsenic Trioxide, and Ascorbic Acid for the Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Phase I Study
    Welch JS, Klco JM, Gao F, Procknow E, Uy GL, Stockerl-Goldstein KE, Abboud CN, Westervelt P, Dipersio JF, Hassan A, Cashen AF, Vij R
    Am J Hematol 2011 Sep;86(9):796-800
  • Use of Whole-Genome Sequencing to Diagnose a Cryptic Fusion Oncogene
    Welch JS*, Westervelt P*, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, Tomasson MH, Link DC, Graubert TA, Dipersio JF, Mardis ER, Ley TJ, Wilson RK (*contributed equally)
    JAMA 2011 Apr 20;305(15):1577-1584
  • Sequencing a Mouse Acute Promyelocytic Leukemia Genome Reveals Genetic Events Relevant for Disease Progression
    Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, Koboldt DC, McLellan MD, Schmidt H, Fulton RS, Abbott RM, Cook L, McGrath SD, Fan X, Dukes AF, Vickery T, Kalicki J, Lamprecht TL, Graubert TA, Tomasson MH, Mardis ER, Wilson RK, Ley TJ
    J Clin Invest 2011 Apr 1;121(4):1445-1455
  • PML-RARA Can Increase Hematopoietic Self-Renewal Without Causing a Myeloproliferative Disease in Mice
    Welch JS, Yuan W, Ley TJ
    J Clin Invest 2011 Apr 1;121(4):1636-45
  • Rara Haploinsufficiency Modestly Influences the Phenotype of Acute Promyelocytic Leukemia in Mice
    Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ
    Blood 2011 Feb 24;117(8):2460-8
  • DNMT3A Mutations in Acute Myeloid Leukemia
    Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
    N Engl J Med 2010 Dec 16;363(25):2424-33
  • A Protease-Resistant PML-RAR{alpha} Has Increased Leukemogenic Potential in a Murine Model of Acute Promyelocytic Leukemia
    Uy GL, Lane AA, Welch JS, Grieselhuber NR, Payton JE, Ley TJ
    Blood 2010 Nov 4;116(18):3604-10
  • Limited Engraftment of Low-Risk Myelodysplastic Syndrome Cells in NOD/SCID Gamma-C Chain Knockout Mice
    Martin MG, Welch JS, Uy GL, Fehniger TA, Kulkarni S, Duncavage EJ, Walter MJ
    Leukemia 2010 Sep;24(9):1662-4
  • Salvage Therapy for Acute Myeloid Leukemia With Fludarabine, Cytarabine, and Idarubicin With or Without Gemtuzumab Ozogamicin and With Concurrent or Sequential G-CSF
    Martin MG, Augustin KM, Uy GL, Welch JS, Hladnik L, Goyal S, Tiwari D, Monahan RS, Reichley RM, Cashen AF, Stockerl-Goldstein K, Westervelt P, Abboud CN, DiPersio JF, Vij R
    Am J Hematol 2009 Nov;84(11):733-7
  • Therapy Related Acute Myeloid Leukemia in Breast Cancer Survivors, a Population-Based Study
    Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ
    Breast Cancer Res Treat 2009 Dec;118(3):593-8
  • Cladribine in the Treatment of Acute Myeloid Leukemia: A Single-Institution Experience
    Martin MG, Welch JS, Augustin K, Hladnik L, DiPersio JF, Abboud CN
    Clin Lymphoma Myeloma 2009 Aug;9(4):298-301
  • Interleukin-4 Induction of the CC Chemokine TARC (CCL17) in Murine Macrophages Is Mediated by Multiple STAT6 Sites in the TARC Gene Promoter
    Liddiard K, Welch JS, Lozach J, Heinz S, Glass CK, Greaves DR
    BMC Mol Biol 2006 Nov 29;7:45
  • Ritual in Western Medicine and Its Role in Placebo Healing
    Welch JS
    The Journal of Religion and Health 2003;42:21-34
  • Why Bad Things Happen at All: A Search for Clarity Among the Problems of Evil
    Welch JS
    BYU Studies 2003;42:75-90
  • Genomics and Inductive Reasoning: Revolution, Renaissance, or Rhetoric?
    Welch JS, Rogler G
    Genet Med 2003 Nov-Dec;5(6):476-8
  • PPARgamma and PPARdelta Negatively Regulate Specific Subsets of Lipopolysaccharide and IFN-Gamma Target Genes in Macrophages
    Welch JS*, Ricote M*, Akiyama TE, Gonzalez FJ, Glass CK (*contributed equally)
    Proc Natl Acad Sci U S A 2003 May 27;100(11):6712-7
  • TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-Dependent Mechanism
    Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK
    J Biol Chem 2002 Nov 8;277(45):42821-9
  • Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray
    Napoli C, de Nigris F, Welch JS, Calara FB, Stuart RO, Glass CK, Palinski W
    Circulation 2002 Mar 19;105(11):1360-7
  • 15-Deoxy-Delta 12,14-Prostaglandin J2 Inhibits Multiple Steps in the NF-Kappa B Signaling Pathway
    Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, Glass CK
    Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4844-9
  • Interleukin-4-Dependent Production of PPAR-Gamma Ligands in Macrophages by 12/15-Lipoxygenase
    Huang JT*, Welch JS*, Ricote M*, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK (*contributed equally)
    Nature 1999 Jul 22;400(6742):378-82
  • Differential Utilization of Ras Signaling Pathways by Macrophage Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Receptors During Macrophage Differentiation
    Guidez F, Li AC, Horvai A, Welch JS, Glass CK
    Mol Cell Biol 1998 Jul;18(7):3851-61
  • Expression of the Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) in Human Atherosclerosis and Regulation in Macrophages by Colony Stimulating Factors and Oxidized Low Density Lipoprotein
    Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK
    Proc Natl Acad Sci U S A 1998 Jun 23;95(13):7614-9

Invited Publications

  • Expanding Dasatinib Beyond KIT in Acute Myeloid Leukemia
    Welch JS
    Haematologica 2020 Dec 1;105(12):2708-2710
  • Patterns of Mutations in TP53 Mutated AML
    Welch JS
    Best Pract Res Clin Haematol 2018 Dec;31(4):379-383
  • Acute Myeloid Leukemia: The Good, the Bad, and the Ugly
    Kuykendall A, Duployez N, Boissel N, Lancet JE, Welch JS
    Am Soc Clin Oncol Educ Book 2018 May 23;(38):555-573
  • マウス造血細胞の内在性レチノイドX受容体リガンド
    Niu H, Fujiwara H, di Martino O, Hadwiger G, Frederick TE, Menéndez-Gutiérrez MP, Ricote M, Bowman GR, Welch JS
    Japanese Scientists in Science Signaling 2018; 20-21
  • Origin of Mutations in Acute Myeloid Leukemia
    Welch JS
    Annals of Hematology 2017;96(Suppl 1):S42-43
  • Mutation Position Within Evolutionary Subclonal Architecture in AML
    Welch JS
    Semin Hematol 2014 Oct;51(4):273-81
  • Genomics of AML: Clinical Applications of Next-Generation Sequencing
    Welch JS, Link DC
    Hematology Am Soc Hematol Educ Program 2011;2011:30-5
  • State of the Art in Myeloid Sarcoma
    Klco JM, Welch JS, Nguyen TT, Hurley MY, Kreisel FH, Hassan A, Lind AC, Frater JL
    Int J Lab Hematol 2011 Dec;33(6):555-65
  • Procarbazine; Mitoxantrone; Daunorubicin; Daunorubicin Liposomal; Doxorubicin; Doxorubicin Liposomal
    Welch JS
    In: Butler SK, Govindan R, eds. "Essential Cancer Pharmacology." Philadelphia: Lippincott Williams & Wilkins, 2011
  • Molecular Therapies
    Martin MG, Welch JS, Abboud CN
    In: Advani A, Lazarus HM, eds. "Adult Acute Lymphocytic Leukemia." Totowa: Humana Press, 2011: 257-276
  • Acute Leukemias
    Welch JS, Cashen A
    In: Govindan R, ed. "Devita, Hellman, and Rosenberg's Cancer Principles and Practice of Oncology Review." Philadelphia: Lippincott Williams & Wilkins, 2009: 423-433
  • The Myeloproliferative Disorders
    Welch JS, Martin MG
    In: Wildes T, ed. "The Washington Manual Hematology and Oncology Subspecialty Consult." Philadelphia: Lippincott Williams & Wilkins, 2008: 90-102
  • The Leukemias
    Martin MG, Welch JS
    In: Wildes T, ed. "The Washington Manual Hematology and Oncology Subspecialty Consult." Philadelphia: Lippincott Williams & Wilkins, 2008: 308-322
  • Oncologic Emergencies
    Welch J, Denes A
    In: Bedient T, ed. "The Washington Manual of Critical Care." Philadelphia: Lippincott Williams & Wilkins, 2008: 216-225
  • Hematological Malignancies: Chronic Leukemias
    Fehniger TA, Welch JS, Pluard TJ
    In: Govindan R, ed. "The Washington Manual of Oncology." Philadelphia: Lippincott Williams & Wilkins, 2008: 319-332
  • Nuclear Receptors as Regulators of Macrophage Homeostasis and Function
    Welch JS, Glass CK
    In: Gordon S, ed. "The Macrophage as Therapeutic Target." New York: Springer, 2003: 209-227
  • Regulation of Macrophage Gene Expression by the Peroxisome Proliferator-Activated Receptor-Gamma
    Ricote M, Welch JS, Glass CK
    Horm Res 2000;54(5-6):275-80
  • The Peroxisome Proliferator-Activated Receptor(PPARgamma) as a Regulator of Monocyte/Macrophage Function
    Ricote M, Huang JT, Welch JS, Glass CK
    J Leukoc Biol 1999 Nov;66(5):733-9