David A. Russler-Germain

David A. Russler-Germain, MD, PhD

Third-year Fellow

Began fellowship in 2019


2005-2009 BS, Stanford University, Stanford, CA
2009-2017 MD/PhD, Washington University School of Medicine, St. Louis, MO
Post-graduate Training
2017-2019 Residency, Internal Medicine, Barnes-Jewish Hospital, St. Louis, MO


  • Donor Memory-Like NK Cells Persist and Induce Remissions in Pediatric Patients With Relapsed AML After Transplant
    Bednarski JJ, Zimmerman C, Berrien-Elliott MM, Foltz JA, Becker-Hapak M, Neal CC, Foster M, Schappe T, McClain E, Pence PP, Desai S, Kersting-Schadek S, Wong P, Russler-Germain DA, Fisk B, Lie WR, Eisele J, Hyde S, Bhatt ST, Griffith OL, Griffith M, Petti AA, Cashen AF, Fehniger TA
    Blood 2022 Mar 17;139(11):1670-1683
  • Hematopoietic Cell Transplantation Donor-Derived Memory-Like NK Cells Functionally Persist After Transfer Into Patients With Leukemia
    Berrien-Elliott MM, Foltz JA, Russler-Germain DA, Neal CC, Tran J, Gang M, Wong P, Fisk B, Cubitt CC, Marin ND, Zhou AY, Jacobs MT, Foster M, Schappe T, McClain E, Kersting-Schadek S, Desai S, Pence P, Becker-Hapak M, Eisele J, Mosior M, Marsala L, Griffith OL, Griffith M, Khan SM, Spencer DH, DiPersio JF, Romee R, Uy GL, Abboud CN, Ghobadi A, Westervelt P, Stockerl-Goldstein K, Schroeder MA, Wan F, Lie WR, Soon-Shiong P, Petti AA, Cashen AF, Fehniger TA
    Sci Transl Med 2022 Feb 23;14(633):eabm1375
  • Idecabtagene Vicleucel: Questions Regarding the Appropriate Role and Cost
    Powell K, Russler-Germain D, Prasad V
    Br J Haematol 2022 Jan;196(2):e15-e16
  • Increased Early Mortality After Fludarabine and Melphalan Conditioning With Peripheral Blood Grafts in Haploidentical Hematopoietic Cell Transplantation With Post-Transplant Cyclophosphamide
    Eastburg L, Russler-Germain DA, DiPersio JF, Fountaine T, Andolina JR, Abboud R, Huselton E
    Leuk Lymphoma 2022 Jan;63(1):222-226
  • Molecular Biology of Cancer
    Russler-Germain D, Aranha O
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, 5th Edition (Morgensztern D, Govindan R, Devarakonda S, Trikalinos NA, Editors), Wolters Kluwer, Philadelphia, 2022
  • A Fusion Protein Complex That Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy
    Becker-Hapak MK, Shrestha N, McClain E, Dee MJ, Chaturvedi P, Leclerc GM, Marsala LI, Foster M, Schappe T, Tran J, Desai S, Neal CC, Pence P, Wong P, Wagner JA, Russler-Germain DA, Zhu X, Spanoudis CM, Gallo VL, Echeverri CA, Ramirez LL, You L, Egan JO, Rhode PR, Jiao JA, Muniz GJ, Jeng EK, Prendes CA, Sullivan RP, Berrien-Elliott MM, Wong HC, Fehniger TA
    Cancer Immunol Res 2021 Sep;9(9):1071-1087
  • Memory-Like Differentiation Enhances NK Cell Responses to Melanoma
    Marin ND, Krasnick BA, Becker-Hapak M, Conant L, Goedegebuure SP, Berrien-Elliott MM, Robbins KJ, Foltz JA, Foster M, Wong P, Cubitt CC, Tran J, Wetzel CB, Jacobs M, Zhou AY, Russler-Germain D, Marsala L, Schappe T, Fields RC, Fehniger TA
    Clin Cancer Res 2021 Sep 1;27(17):4859-4869
  • A Forgotten Friend: CCNU as Palliative Monotherapy in Relapsed Hodgkin Lymphoma
    Russler-Germain DA, Watkins MP, Bartlett NL
    Leuk Lymphoma 2021 Feb;62(2):486-488
  • Incidence of Metastatic Prostate Cancer on the Rise
    Russler-Germain DA, Kahl BS
    Oncology (Williston Park) 2020 Dec 7;34(12):522-534
  • Haploinsufficiency for DNA Methyltransferase 3A Predisposes Hematopoietic Cells to Myeloid Malignancies
    Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, Ley TJ
    J Clin Invest 2017 Oct 2;127(10):3657-3674
  • CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816e13
  • PML-RARA Requires DNA Methyltransferase 3A to Initiate Acute Promyelocytic Leukemia
    Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ
    J Clin Invest 2016 Jan;126(1):85-98
  • Registered Report: IDH Mutation Impairs Histone Demethylation and Results in a Block to Cell Differentiation
    Richarson AD, Scott DA, Zagnitko O, Aza-Blanc P, Chang CC, Russler-Germain DA
    Elife 2016 Mar 11;5:e10860
  • The R882H DNMT3A Mutation Associated With AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
    Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ
    Cancer Cell 2014 Apr 14;25(4):442-54
  • Microtubules Provide Directional Information for Core PCP Function
    Matis M, Russler-Germain DA, Hu Q, Tomlin CJ, Axelrod JD
    Elife 2014 Aug 14;3:e02893
  • Electron Tomography of Degenerating Neurons in Mice With Abnormal Regulation of Iron Metabolism
    Zhang P, Land W, Lee S, Juliani J, Lefman J, Smith SR, Germain D, Kessel M, Leapman R, Rouault TA, Subramaniam S
    J Struct Biol 2005 May;150(2):144-53