Fellows
Joshua I. Siner

Joshua I. Siner, MD

First-year Fellow

Began fellowship in 2021

Biosketch

Education
2006-2010 BS, Biochemistry and Molecular Biology, Gettysburg College, Gettysburg, PA
2011-2012 Pre-Health, Specialized Studies, University of Pennsylvania, Philadelphia, PA
2014-2018 MD, Cooper Medical School of Rowan University, , Camden, NJ
Work Experience
2010-2014 Research Technician (laboratory of Valder Arruda MD, PhD), The Children's Hospital of Philadelphia, Philadelphia, PA
Post-Graduate Training
2018-2021 Internal Medicine Residency, Brown University / Rhode Island Hospital, The Miriam Hospital and Providence VA Medical Center, Providence, RI
Honors & Awards
2012 Oral Presentation Prize; Philadelphia Workshop on Hemostasis, Thrombosis and Atherosclerosis
2012 Abstract Achievement Award; American Society of Hematology
2013 Research Poster Day Presentation Prize; The Children’s Hospital of Philadelphia
2014 Meritorious Abstract Travel Award; American Society of Gene & Cell Therapy
2014 ASH Outstanding Abstract Achievement Award (Highest rated abstract for a Medical Student); American Society of Hematology
2015 Hematology Opportunities for the Next Generation of Research Scientists (HONORS); American Society of Hematology
2016 Trainee Travel Award; Thrombosis and Hemostasis Societies of North America Summit
Gold Humanism Honor Society

Peer-reviewed Journal Articles

  • Novel Factor VIII Variants With a Modified Furin Cleavage Site Improve the Efficacy of Gene Therapy for Hemophilia A
    Nguyen GN, George LA, Siner JI, Davidson RJ, Zander CB, Zheng XL, Arruda VR, Camire RM, Sabatino DE
    J Thromb Haemost 2017 Jan;15(1):110-121
  • Circumventing Furin Enhances Factor VIII Biological Activity and Ameliorates Bleeding Phenotypes in Hemophilia Models
    Siner JI, Samelson-Jones BJ, Crudele JM, French RA, Lee BJ, Zhou S, Merricks E, Raymer R, Nichols TC, Camire RM, Arruda VR
    JCI Insight 2016 Oct 6;1(16):e89371
  • AAV Liver Expression of FIX-Padua Prevents and Eradicates FIX Inhibitor Without Increasing Thrombogenicity in Hemophilia B Dogs and Mice
    Crudele JM, Finn JD, Siner JI, Martin NB, Niemeyer GP, Zhou S, Mingozzi F, Lothrop CD Jr, Arruda VR
    Blood 2015 Mar 5;125(10):1553-61
  • Minimal Modification in the Factor VIII B-Domain Sequence Ameliorates the Murine Hemophilia A Phenotype
    Siner JI, Iacobelli NP, Sabatino DE, Ivanciu L, Zhou S, Poncz M, Camire RM, Arruda VR
    Blood 2013 May 23;121(21):4396-403
  • Safety of Liver Gene Transfer Following Peripheral Intravascular Delivery of Adeno-Associated Virus (AAV)-5 and AAV-6 in a Large Animal Model
    Favaro P, Finn JD, Siner JI, Wright JF, High KA, Arruda VR
    Hum Gene Ther 2011 Jul;22(7):843-52